Lab focus
The goal of our group is to study how deficits in brain development affect cognitive function. We start from the identification of genes which cause neurodevelopmental disorders such as intellectual disability, autism spectrum disorder, or brain malformations, and then use animal models (mouse and zebrafish) to recapitulate the human disease, understand pathogenesis and study the molecular mechanisms of development. We are particularly interested in intracellular signaling and glycosylation deficits that could be targeted for the development of novel therapies.
Contact
M. Chiara Manzini PhD
Child Health Institute of New Jersey
Rutgers-Robert Wood Johnson Medical School
Dept. of Neuroscience and Cell Biology
89 French Street rm 3274
New Brunswick, NJ 08901
Child Health Institute of New Jersey
Rutgers-Robert Wood Johnson Medical School
Dept. of Neuroscience and Cell Biology
89 French Street rm 3274
New Brunswick, NJ 08901
Latest lab news
7/6/24 - Aniket's paper on the analysis of variants of unknown significance in a rare form of intellectual disability and autism is out today in Human Molecular Genetics! Available online at OUP
6/11/24 - The lab attended the first retreat for the Department of Neuroscience and Cell Biology and had a blast...and won awards. See Aniket's great summary here.
6/1/24 - We have multiple new undergraduate students joining us for the summer: Callista Oliveira, Cynthia Venkantesan and Diya Patel...with Harshini Ganesh, Ashini Bhardwaj and Emma Suzuki staying on.
5/12/24 - Chiara and Abby are in Italy attending the Gordon Research Conference on Fragile X and Autism related disorders. See Abby's post on LinkedIn.
2/1/24 - Sylvia's thesis work in collaboration with Kyle defining the genetic causes of severe congenital muscular dystrophy with brain malformations in Egypt is out in neurogenetics. Open Access at Springer.
1/25/24 - One more paper out this week. Brittany Karas and Kristin Terez' major opus on the zebrafish pomt1 mutant model of congenital muscle disease showing that "Moms matter". Available online at OUP.
1/18/24 - See new guidelines for drug screening in zebrafish muscle disease models we contributed to in collaboration with multiple investigator led by Matt Alexander at UAB. Published in Disease Models & Mechanisms today.
7/6/24 - Aniket's paper on the analysis of variants of unknown significance in a rare form of intellectual disability and autism is out today in Human Molecular Genetics! Available online at OUP
6/11/24 - The lab attended the first retreat for the Department of Neuroscience and Cell Biology and had a blast...and won awards. See Aniket's great summary here.
6/1/24 - We have multiple new undergraduate students joining us for the summer: Callista Oliveira, Cynthia Venkantesan and Diya Patel...with Harshini Ganesh, Ashini Bhardwaj and Emma Suzuki staying on.
5/12/24 - Chiara and Abby are in Italy attending the Gordon Research Conference on Fragile X and Autism related disorders. See Abby's post on LinkedIn.
2/1/24 - Sylvia's thesis work in collaboration with Kyle defining the genetic causes of severe congenital muscular dystrophy with brain malformations in Egypt is out in neurogenetics. Open Access at Springer.
1/25/24 - One more paper out this week. Brittany Karas and Kristin Terez' major opus on the zebrafish pomt1 mutant model of congenital muscle disease showing that "Moms matter". Available online at OUP.
1/18/24 - See new guidelines for drug screening in zebrafish muscle disease models we contributed to in collaboration with multiple investigator led by Matt Alexander at UAB. Published in Disease Models & Mechanisms today.